Zithromax (Azithromycin) Z-Pak (250 mg Tablets)
The Zithromax Z-PAK (500 mg qd day 1, followed by 250 mg qd for 4 days) is indicated for community-acquired pneumonia (CAP) due to Chlamydia pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus pneumoniae, for patients appropriate for oral therapy.
| Medication |
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| Zithromax (Generic) 250mg |
18 |
$146.00 |
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| Zithromax (Generic) 250mg |
6 |
$82.00 |
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| Zithromax Z-Pac (6 pills) |
6 |
$108.00 |
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Oral azithromycin should not be used in patients with pneumonia who are judged to be inappropriate for oral therapy because of moderate to severe illness or risk factors, such as: cystic fibrosis, nosocomially acquired infections, or known or suspected bacteremia; or in those who require hospitalization, are elderly or debilitated, or have significant underlying health problems that may compromise their ability to respond to their illness (including immunodeficiency or functional asplenia).
Data summarized from 8 comparative studies and 2 noncomparative studies of patients with pneumonia documented by x-ray proved that a standard course of Zithromax delivered overall clinical response* rates similar to comparative agents† in patients of varying ages (88% for both groups). This study also demonstrated comparable clinical response rates in the subset of patients 16 to 60 years (92% for Zithromax and 95% for comparatives agents) as well as in the subset of patients above 60 years of age (82% and 78%, respectively). Zithromax also delivered high bacteriologic response rates‡ vs comparative agents in patients with community-acquired pneumonia: Streptococcus pneumoniae (93% for Zithromax and 95% for comparative agents) and Haemophilus influenzae (100% for Zithromax and 85% for comparative agents).
Zithromax is rapidly and extensively taken up by leukocytes, which deliver the drug to the site of infection, where Zithromax maintains high sustained concentrations.§ Zithromax also has a long half-life (68 hours) allowing for its convenient 5-day dosing regimen.
The Zithromax Z-PAK also offers excellent tolerability, with a low incidence of adverse events. The most common side effects of Zithromax are diarrhea/loose stools (4%-5%), nausea (3%), and abdominal pain (2%-3%) and the overall discontinuation rate is 0.7%. Zithromax has not demonstrated an inhibitory effect on the cytochrome P450 system. Zithromax is designated pregnancy category B.
Zithromax is contraindicated in patients with known hypersensitivity to any macrolide antibiotic.
If an allergic reaction occurs, the drug should be discontinued and appropriate therapy instituted. Physicians should be aware that reappearance of allergic symptoms may occur when symptomatic therapy for the allergic reaction is discontinued.
Pseudomembranous colitis has been reported with nearly all antibacterial agents. It is important to consider this diagnosis in patients who present with diarrhea.
*Clinical response = cured + improved.
†Comparative agents included cefaclor, amoxicillin, erythromycin, amoxicillin/clavulanate, and josamycin dosed tid or qid for 7 to 10 days as appropriate.
‡Bacteriologic response rate at end of therapy was classified as eradication (if the susceptible pathogen present at baseline was eradicated) or persistent (if the susceptible pathogen was still present).
§High tissue concentrations should not be interpreted to be quantitatively related to efficacy.
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